• APOE RECEPTORS
• PROGRAM PROJECT GRANT
• PROTOCOLS & REAGENTS

Most of the apoE functions identified both in vitro and in vivo appear to be modulated, if not dependent upon, a distinct set of apoE receptors

As a scientific community we are working to further understand the functions of apoE receptors including:

• Interactions with APP processing
• Aβ clearance/deposition
• Synaptic function
• Cholesterol homeostasis
• Microtubial stability/axonal transport

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• APOE RECEPTORS
• PROGRAM PROJECT GRANT
• PROTOCOLS & REAGENTS

The goal of this Program is to take advantage of the overlapping interests and diverse expertise of five scientists examining the biology of apoE and apoE receptors in the CNS.

The specific aims of this project include understanding the functions of apoE receptors including:

• Effect of the three apoE isoforms
• Intracellular signaling
• Trafficking/metabolism
• Genetic regulation & receptor processing
• Neuroplasticity/behavior

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• APOE RECEPTORS
• PROGRAM PROJECT GRANT
• PROTOCOLS & REAGENTS

One of the goals of the program project is to develop a unique collection of apoE/apoE receptor reagents and protocols. As possible these may be made available on a limited basis to the general scientific communities.

These reagents include:

• Specific antibodies for the apoE receptor family
• cDNAs and cell lines
• New transgenic mouse crosses

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